反应详情

温度

72 °C

To a solution of 4-(3-diethylamino-propoxy)-phenylamine (913 mg, 1.3 equiv.) in THF (14 mL) is added 4-methyl-3-hydroxymethylene-1,3-dihydro-indol-2-one (554 mg, 3.17 mmol) in one portion. The resulting reaction mixture is stirred and heated at 72° C. overnight. The reaction solution is cooled to room temperature and partitioned between EtOAc:H2O. The organic layer is collected and washed with saturated aqueous NaHCO3 and dried over anhydrous Na2SO4. The organic phase is filtered and concentrated. The residue obtained is triturated with 1:4 EtOAc:hexane to give the named compound as a yellow solid (625.8 mg, 52%).

1. customThe resulting reaction mixture
2. temperatureThe reaction solution is cooled to room temperature
3. custompartitioned between EtOAc
4. customThe organic layer is collected
5. washwashed with saturated aqueous NaHCO3
6. dry with materialdried over anhydrous Na2SO4
7. filtrationThe organic phase is filtered
8. concentrationconcentrated
9. customThe residue obtained
10. customis triturated with 1:4 EtOAc