Tetrahydrofuran → 1-Cyclohexyl-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

HRID 1150747Notes

Reaction equation

HRID 1150747 reaction equation
[C:9]([Li:10])([CH3:11])([CH3:12])[CH3:13].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH:1]1([CH2:7][Br:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[F:14][c:15]1[cH:16][cH:17][c:18]([O:33][CH3:34])[c:19]([C:21]([CH2:22][C:23](=[O:24])[N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)([CH3:31])[CH3:32])[cH:20]1>>[CH:1]1([CH2:7][C:23]([CH2:22][C:21]([c:19]2[c:18]([O:33][CH3:34])[cH:17][cH:16][c:15]([F:14])[cH:20]2)([CH3:31])[CH3:32])=[O:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 137636Cyclohexane, (bromomethyl)-HCID 223985283-(5-Fluoro-2-methoxyphenyl)-3-methyl-1-morpholin-4-ylbutan-1-oneHCID 178418306HCID 178418306, compound

Product 1

HCID 223986261-Cyclohexyl-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

Sources & evidence

ORD record
ord-51b3e9fc6a4c432db5f18ba9822ac68d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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