Dichloromethane → Aliskiren inter-10

HRID 1151073Notes

Reaction equation

HRID 1151073 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH:8]1[N:9]([C:14]([CH2:15][CH:16]([CH3:17])[CH3:18])=[O:19])[C:10](=[O:13])[O:11][CH2:12]1.[CH:20]([N:21]([CH2:22][CH3:23])[CH:24]([CH3:25])[CH3:26])([CH3:27])[CH3:28].[Cl:29][CH2:30][O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[Cl:39][CH2:40][Cl:41]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH:8]1[N:9]([C:14]([CH:15]([CH:16]([CH3:17])[CH3:18])[CH2:30][O:31][CH2:32][c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)=[O:19])[C:10](=[O:13])[O:11][CH2:12]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 137983Benzyl chloromethyl etherHCID 155977734-Benzyl-3-(3-methylbutanoyl)-1,3-oxazolan-2-one

Product 1

HCID 21950155Aliskiren inter-10

Sources & evidence

ORD record
ord-40580e486adb4c75a2e6a1082ab079c2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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