Dichloromethane → 1-[5-(1-fluoromethyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-{1-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-urea

HRID 1151237Notes

Reaction equation

HRID 1151237 reaction equation
[C:19](=[O:20])([n:21]1[cH:22][cH:23][n:24][cH:25]1)[n:26]1[cH:27][cH:28][n:29][cH:30]1.[Cl:55][CH2:56][Cl:57].[F:1][CH2:2][C:3]1([c:6]2[cH:7][c:8]([NH2:18])[n:9](-[c:11]3[cH:12][cH:13][c:14]([CH3:17])[cH:15][cH:16]3)[n:10]2)[CH2:4][CH2:5]1.[NH2:31][c:32]1[cH:33][n:34][c:35]([O:42][CH:43]2[CH2:44][CH2:45][N:46]([C:49](=[O:50])[C:51]3([CH3:54])[CH2:52][CH2:53]3)[CH2:47][CH2:48]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]12>>[F:1][CH2:2][C:3]1([c:6]2[cH:7][c:8]([NH:18][C:19](=[O:20])[NH:31][c:32]3[cH:33][n:34][c:35]([O:42][CH:43]4[CH2:44][CH2:45][N:46]([C:49](=[O:50])[C:51]5([CH3:54])[CH2:52][CH2:53]5)[CH2:47][CH2:48]4)[c:36]4[cH:37][cH:38][cH:39][cH:40][c:41]34)[n:9](-[c:11]3[cH:12][cH:13][c:14]([CH3:17])[cH:15][cH:16]3)[n:10]2)[CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 682631,1'-CarbonyldiimidazoleHCID 57832814[4-(4-Amino-isoquinolin-1-yloxy)-piperidin-1-yl]-(1-methyl-cyclopropyl)-methanoneHCID 685381145-(1-fluoromethyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-ylamine

Product 1

HCID 578328051-[5-(1-fluoromethyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-{1-[1-(1-methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-urea

Sources & evidence

ORD record
ord-2596b517ed8a4a58adedb65414acb493
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…