4-(3-(Diethylamino)propoxy)-3-fluoroaniline → HCID 178418944, compound

HRID 11518Notes

Reaction equation

HRID 11518 reaction equation
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[F:15])[CH3:2].O[CH:19]=[C:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][C:21]1=[O:29]>>[CH2:16]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH:19]=[C:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][C:21]2=[O:29])=[CH:10][C:9]=1[F:15])[CH3:17]

Participants

3

Reactant 2

HCID 219747414-(3-(Diethylamino)propoxy)-3-fluoroanilineHCID 1784187413-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178418944HCID 178418944, compoundYield 24%

Procedure

In a manner similar to that described in Example 231, 4-(3-Diethylamino-propoxy)-3-fluoro-phenylamine (400 mg, 1.1 equiv.) and 3-hydroxymethylene-1,3-dihydro-indol-2-one (242 mg, 1.5 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (135 mg, 24%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-917046f5e1ea4624a55632873b38e4e0
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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