Chloride → 2-(4-(2,2,2-Trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

HRID 1152329Notes

Reaction equation

HRID 1152329 reaction equation
[CH2:1]([O:2][C:4](=[O:5])[C:6]1([CH2:13][CH2:14][O:3][CH3:15])[CH2:7][C:8](=[O:12])[NH:9][CH2:10][CH2:11]1)[CH3:16].[CH3:18][Al+:19][CH3:20].[Cl-:17].[F:21][C:22]([CH2:23][O:24][c:25]1[cH:26][cH:27][c:28]([NH2:31])[cH:29][cH:30]1)([F:32])[F:33]>>[C:4]1(=[O:5])[C:6]2([CH2:7][C:8](=[O:12])[NH:9][CH2:10][CH2:11]2)[CH2:13][CH2:14][N:31]1[c:28]1[cH:27][cH:26][c:25]([O:24][CH2:23][C:22]([F:21])([F:32])[F:33])[cH:30][cH:29]1

Participants

5

Reactant 4

HCID 312ChlorideHCID 27771194-(2,2,2-Trifluoroethoxy)anilineHCID 16685399DimethylalumanyliumHCID 584784144-(2-Methoxy-ethyl)-2-oxo-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 584784102-(4-(2,2,2-Trifluoroethoxy)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione

Sources & evidence

ORD record
ord-79375ced6e0e40fe874d698c4adb5fd7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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