Trityl chloride → (3RS,4RS,5SR)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-trityloxymethyl-piperidine-1-carboxylic acid tert-butyl ester

HRID 1152509Notes

Reaction equation

HRID 1152509 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([OH:36])[CH:11]([c:16]2[cH:17][cH:18][c:19]([O:22][CH2:23][CH2:24][CH2:25][O:26][CH2:27][c:28]3[c:29]([O:34][CH3:35])[cH:30][cH:31][cH:32][cH:33]3)[cH:20][cH:21]2)[CH:12]([CH2:14][OH:15])[CH2:13]1.[c:37]1([C:43]([Cl:44])([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[cH:38][cH:39][cH:40][cH:41][cH:42]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([OH:36])[CH:11]([c:16]2[cH:17][cH:18][c:19]([O:22][CH2:23][CH2:24][CH2:25][O:26][CH2:27][c:28]3[c:29]([O:34][CH3:35])[cH:30][cH:31][cH:32][cH:33]3)[cH:20][cH:21]2)[CH:12]([CH2:14][O:15][C:43]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[CH2:13]1

Participants

3

Reactant 2

HCID 6456Trityl chlorideHCID 54246339(3RS,4RS,5SR)-3-hydroxy-5-hydroxymethyl-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 53659348(3RS,4RS,5SR)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-trityloxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-97672bbf702a43d8bc34f97c84b66c58
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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