Methanol → 4,4-Difluoro-5-(2-fluoropyridin-3-yl)pyrrolidin-3-yl 4-methylbenzenesulfonate

HRID 1152793Notes

Reaction equation

HRID 1152793 reaction equation
[BH4-:26].[CH3:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[O:11][CH:12]2[CH2:13][N:14]=[C:15]([c:19]3[c:20]([F:25])[n:21][cH:22][cH:23][cH:24]3)[C:16]2([F:17])[F:18])[cH:6][cH:7]1.[CH3:28][OH:29].[Na+:27].[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[O:11][CH:12]2[CH2:13][NH:14][CH:15]([c:19]3[c:20]([F:25])[n:21][cH:22][cH:23][cH:24]3)[C:16]2([F:17])[F:18])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 28123BorohydrideHCID 583498384,4-Difluoro-5-(2-fluoropyridin-3-yl)-3,4-dihydro-2H-pyrrol-3-yl 4-methylbenzenesulfonate

Product 1

HCID 866397284,4-Difluoro-5-(2-fluoropyridin-3-yl)pyrrolidin-3-yl 4-methylbenzenesulfonate

Sources & evidence

ORD record
ord-6dd2db8ef7b54754950e7c1731e7e245
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…