2-Acetylhydroquinone → HCID 11322818, compound

Participants

Reaction Steps

To a solution of 4 g of 2-acetyl hydroquinone (I) in 90 ml of ethyl acetate, 100 ml of acetonitrile and 5 ml of benzyl alcohol (III) are added 60 g of crushed calcium sulfate oven dried at 240° C., then 8.5 g of powdered cuprous chloride. It is agitated in gaseous oxygen (at a pressure of one atmosphere) for two hours and thirty minutes at ambient temperature. Then it is diluted with toluene, filtered, the filtrate is evaporated, the residue taken up in a mixture of 120 ml of ether and 80 ml of cyclohexane; by trituration of the resulting mixture followed by a filtration separation of the insoluble matter, a solution is obtained which leads to the expected compound (Yield≃70%) after evaporation of the solvents.

Provenance & Evidence