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HRID1153703

反应详情

EQUATION

反应方程式

HRID 1153703 的结构方程式

REACTANTS

反应物

5
结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID10133

Chenodeoxycholic acid

C24H40O4

结构：CCSC(=O)N(CC(C)C)CC(C)C
HCID16181

Butylate

C11H23NOS

结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID444262

7-Oxolithocholic acid

C24H38O4

结构：[Na]
HCID5360545

Sodium

Na

结构：[K]
HCID5462222

Potassium

K

PRODUCTS

生成物

1
结构：C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID31401

Ursodeoxycholic acid

C24H40O4

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCO
溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

To a solution of potassium ter.butylate (3.77 g, 33.6 mmols) and 3alpha-hydroxy-7-keto-5beta-cholanic acid (2.5 g, 6.36 mmols) in ter.butyl-alcohol (50 ml), kept at the reflux under nitrogen and under stirring, sodium metal (1.75 g, 0.76 gram-atoms) is added. The reaction mixture is maintained under stirring and reflux for 2 hours and then worked up as disclosed in example 1; 2.5 g of the residue consisting of the CDCA (7%) and the UDCA (93) are thus obtained.

WORKUP

后处理

  1. temperaturereflux under nitrogen
  2. temperatureThe reaction mixture is maintained
  3. stirringunder stirring
  4. temperaturereflux for 2 hours