HCID 20436351, compound → HCID 13385547, compound

HRID 1153727Notes

Reaction equation

HRID 1153727 reaction equation
C([C:3]([N:17]1CCCCC1)([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[CH2:4][CH:5]([CH3:10])[C:6](OC)=[O:7])#N.C(C(C1C=CN=CC=1)(N1CCCC1)CC(C)C(OC)=O)#[N:24].C(C(N1CCOCC1)(C1C=CN=CC=1)CC(C)C(OCC)=O)#N.C(C(C1C=CN=CC=1)(N1CCOCC1)CC(C)C(OCCC)=O)#N>>[CH3:10][CH:5]1[CH2:4][C:3]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[N:17][NH:24][C:6]1=[O:7]

Participants

5

Reactant 4

HCID 20436351HCID 20436351, compoundHCID 20436355HCID 20436355, compoundHCID 20436357HCID 20436357, compoundHCID 20436358HCID 20436358, compound

Product 1

HCID 13385547HCID 13385547, compound

Procedure

Following the above procedure described above for preparing methyl 4-cyano-2-methyl-4-(4-morpholinyl)-4-(4-pyridinyl)butanoate but using in place of 2-(4-morpholinyl)-2-(4-pyridinyl)ethanenitrile and methyl methacrylate molar equivalent quantities respectively of the appropriate 2-(BN)-2-(4-pyridinyl)ethanenitrile and lower-alkyl methacrylate, it is contemplated that there can be obtained the following corresponding lower-alkyl 4-cyano-2-methyl-4-(BN)-2-(4-pyridinyl)butanoates: methyl 4-cyano-2-methyl-4-(1-piperidinyl)-4-(4-pyridinyl)butanoate; methyl 4-cyano-2-methyl-4-(4-pyridinyl)-4-(1-pyrrolidinyl)butanoate; ethyl 4-cyano-2-methyl-4-(4-morpholinyl)-4-(4-pyridinyl)butanoate; and, n-propyl 4-cyano-4-(4-pyridinyl)-2-methyl-4-(4-morpholinyl)butanoate.

Sources & evidence

ORD record
ord-5b955a23b90c40f0814d5a4078f0e694
Source dataset
uspto-grants-1984_12
Patent number
US04486431

Reaction notes

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