HCID 20436351, compound → HCID 13385547, compound

Participants

Reaction Steps

Following the above procedure described above for preparing methyl 4-cyano-2-methyl-4-(4-morpholinyl)-4-(4-pyridinyl)butanoate but using in place of 2-(4-morpholinyl)-2-(4-pyridinyl)ethanenitrile and methyl methacrylate molar equivalent quantities respectively of the appropriate 2-(BN)-2-(4-pyridinyl)ethanenitrile and lower-alkyl methacrylate, it is contemplated that there can be obtained the following corresponding lower-alkyl 4-cyano-2-methyl-4-(BN)-2-(4-pyridinyl)butanoates: methyl 4-cyano-2-methyl-4-(1-piperidinyl)-4-(4-pyridinyl)butanoate; methyl 4-cyano-2-methyl-4-(4-pyridinyl)-4-(1-pyrrolidinyl)butanoate; ethyl 4-cyano-2-methyl-4-(4-morpholinyl)-4-(4-pyridinyl)butanoate; and, n-propyl 4-cyano-4-(4-pyridinyl)-2-methyl-4-(4-morpholinyl)butanoate.

Provenance & Evidence