Potassium Carbonate → HCID 135759101, compound

HRID 1153855Notes

Reaction equation

HRID 1153855 reaction equation
Cl.N[C:3]1[C:4]2[C:5](=[N:15][N:16]([CH3:18])[CH:17]=2)[NH:6][C:7]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:8]=2[N:9]=1.C(=O)([O-])[O-:20].[K+].[K+]>C(O)C.O>[Cl:14][C:11]1[CH:12]=[CH:13][C:7]2[NH:6][C:5]3=[N:15][N:16]([CH3:18])[CH:17]=[C:4]3[C:3](=[O:20])[NH:9][C:8]=2[CH:10]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 135759094HCID 135759094, compound

Product 1

HCID 135759101HCID 135759101, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

4-Amino-7-chloro-2,10-dihydro-2-methylpyrazolo[3,4-b][1,5]benzodiazepine hydrochloride (11.3 g) and potassium carbonate (16.8 g) were heated under reflux in a mixture of ethanol (200 ml) and water (20 ml) for 48 hours. Water (300 ml) was added and the solution cooled. The precipitate was crystallised from acetic acid to give the title compound m.p. >260° C.

Workup

  1. temperaturethe solution cooled
  2. customThe precipitate was crystallised from acetic acid

Sources & evidence

ORD record
ord-467e5708bb27465ebd81bb6fb831e15b
Source dataset
uspto-grants-1984_12
Patent number
US04486591

Reaction notes

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