Potassium Carbonate → HCID 19848800, compound

HRID 1153903Notes

Reaction equation

HRID 1153903 reaction equation
COC1C=C(CNCCCNCCCCNCCCN)C=CC=1O.C(O[C:29]1([CH3:58])[CH2:34][CH:33]([CH:35]([CH2:37][CH2:38][NH:39][C:40](=[O:42])[CH3:41])[CH3:36])[C:32]2C=[CH:44][C:45]([CH:47]([CH2:49][CH2:50][CH2:51][C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)[CH3:48])=[CH:46][C:31]=2[O:30]1)(=O)C.[C:59](=[O:62])([O-])[O-].[K+].[K+]>CO>[C:40]([NH:39][CH2:38][CH2:37][CH:35]([CH:33]1[C:32]2[C:59]([OH:62])=[CH:44][C:45]([CH:47]([CH2:49][CH2:50][CH2:51][C:52]3[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=3)[CH3:48])=[CH:46][C:31]=2[O:30][CH:29]([CH3:58])[CH2:34]1)[CH3:36])(=[O:42])[CH3:41]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 131714009HCID 131714009, compound

Product 1

HCID 19848800HCID 19848800, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 156 mg (0.335 mmole) dl-5-acetoxy-4-(4-acetylamino-2-butyl)-2-methyl-7-(5-phenyl-2-pentyl)-3,4-dihydro-2H-benzopyran and 46 mg (0.333 mmole) potassium carbonate in 40 ml of methanol is stirred at room temperature for two hours. After neutralization with acetic acid the mixture is evaporated in vacuo and the residue taken up in ethyl ether. The ether solution is washed successively with water, saturated sodium bicarbonate, brine and dried over magnesium sulfate. Evaporation of ether affords the title amide.

Workup

  1. customAfter neutralization with acetic acid the mixture is evaporated in vacuo
  2. washThe ether solution is washed successively with water, saturated sodium bicarbonate, brine
  3. dry with materialdried over magnesium sulfate
  4. customEvaporation of ether

Sources & evidence

ORD record
ord-e64e1e1f79d34ec1a80d3716af1ace17
Source dataset
uspto-grants-1984_12
Patent number
US04486428

Reaction notes

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