Chloroform → HCID 54395344, compound

HRID 1153912Notes

Reaction equation

HRID 1153912 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[OH:12][CH2:13][CH2:14][CH:15]1[C:24]2[C:19](=[CH:20][C:21]([CH2:26][CH2:27][CH2:28][S:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:22][C:23]=2[OH:25])[N:18]([CH3:34])[CH:17]([CH3:35])[CH2:16]1.C(Cl)(Cl)Cl>C(O)(=O)C>[OH:12][CH2:13][CH2:14][CH:15]1[C:24]2[C:19](=[CH:20][C:21]([CH2:26][CH2:27][CH2:28][S:29]([CH2:30][CH2:31][CH2:32][CH3:33])=[O:9])=[CH:22][C:23]=2[OH:25])[N:18]([CH3:34])[CH:17]([CH3:35])[CH2:16]1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 70297m-Chloroperbenzoic acidHCID 19848791HCID 19848791, compound

Product 1

HCID 54395344HCID 54395344, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Equimolar amounts of m-chloroperbenzoic acid and dl-4-(2-hydroxyethyl)-5-hydroxy-1,2-dimethyl-7-(4-thiaoctyl)-1,2,3,4-tetrahydroquinoline are added to a mixture of chloroform and acetic acid (2:1 v/v) and the mixture stirred at room temperature for one hour. The mixture is washed with water, the organic phase dried (MgSO4) and evaporated to dryness at reduced pressure to afford the title compound.

Workup

  1. washThe mixture is washed with water
  2. dry with materialthe organic phase dried (MgSO4)
  3. customevaporated to dryness at reduced pressure

Sources & evidence

ORD record
ord-a4fa54ed212245259117227645bbe1eb
Source dataset
uspto-grants-1984_12
Patent number
US04486428

Reaction notes

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