Sodium Hydroxide → HCID 88718078, compound

HRID 1153936Notes

Reaction equation

HRID 1153936 reaction equation
Cl.[CH3:2][N:3]([CH3:5])[CH3:4].[OH-].[Na+].I[CH2:9][CH:10]=[CH:11][C:12]1[CH2:13][S:14][C@@H:15]2[CH:35]([NH:36][C:37](=[O:67])/[C:38](=[N:64]\[O:65][CH3:66])/[C:39]3[N:40]=[C:41]([NH:44]C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[S:42][CH:43]=3)[C:34](=[O:68])[N:16]2[C:17]=1[C:18]([O:20]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:19]>C(OCC)(=O)C.CCCCCC>[NH2:44][C:41]1[S:42][CH:43]=[C:39](/[C:38](=[N:64]/[O:65][CH3:66])/[C:37]([NH:36][CH:35]2[C:34](=[O:68])[N:16]3[C:17]([C:18]([O-:20])=[O:19])=[C:12](/[CH:11]=[CH:10]/[CH2:9][N+:3]([CH3:5])([CH3:4])[CH3:2])[CH2:13][S:14][C@H:15]23)=[O:67])[N:40]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 10313079Trimethylamine HydrochlorideHCID 172930622HCID 172930622, compound

Product 1

HCID 88718078HCID 88718078, compound

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

Trimethylamine hydrochloride (6.31 g, 66 mmole) was added to an aqueous NaOH solution (2N, 33 ml) covered with ethyl acetate (100 ml). The organic layer was separated, dried over NaOH pellets, and added to a suspension of diphenylmethyl 3-(3-iodo-1-propen-1-yl)-7-[(Z)-2-methoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-cephem-4-carboxylate (X-1, 32 g, 33 mmole) in a mixture of ethyl acetate and n-hexane (300 ml/150 ml). The mixture was stirred for one hour at room temperature and then filtered to give the blocked title compound, which was treated with trifluoroacetic acid (50 ml) and anisole (10 ml) for one hour at room temperature. The mixture was concentrated under reduced pressure and the residue was triturated with ether to give 10.3 g of dark brown solid, which was treated with water (100 ml) at room temperature. After removal of insolubles by filtration, the filtrate was chromatographed on a column of HP-20 (200 ml) by eluting with 30% aqueous methanol. The eluate was concentrated and lyophilized to give 2.3 g of the crude title compound, which was purified by preparative HPLC (Waters Associates, System 500, PrepPAK 500/C18, 15% CH3OH) to afford 880 mg (5%) of the title compound I-1D. Estimated purity 75% (by HPLC).

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over NaOH pellets
  3. filtrationfiltered
  4. customto give the

Sources & evidence

ORD record
ord-b83e2b14b0cf4f309776d978b804da66
Source dataset
uspto-grants-1984_12
Patent number
US04486586

Reaction notes

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