Sodium Chloride → L-Penicillamine

HRID 1153957Notes

Reaction equation

HRID 1153957 reaction equation
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].[Cl-].[Na+]>O.C([O-])(=O)C.[Na+]>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4]

Participants

5

Reactant 2

HCID 5234Sodium ChlorideHCID 5852Penicillamine

Product 1

HCID 92863L-Penicillamine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 517045Sodium AcetateSolvent

Procedure

Cupric acetate is dissolved in water to prepare a solution having a concentration of 10 mg Cu++ /ml. D-penicillamine is dissolved in 0.05 molar sodium acetate buffer, pH 5.6, containing 2% sodium chloride to give a concentration of 10 mg penicillamine/ml. The copper solution is added to the penicillamine solution in a ratio of 16 ml of copper solution to 50 ml of penicillamine solution. The ratio of penicillamine to copper in moles is 1.3. The solution immediately takes on a red-violet color indicating the formation of the complex. The solution is dried to yield a powder and formed into tablets each containing 10 mg of the combination.

Workup

  1. customto prepare a solution

Sources & evidence

ORD record
ord-c5a617c0588a4f3b9b8d01a4f34bc5e3
Source dataset
uspto-grants-1984_12
Patent number
US04487780

Reaction notes

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