Sodium Chloride → L-Penicillamine

Participants

Reaction Steps

Cupric acetate is dissolved in water to prepare a solution having a concentration of 10 mg Cu++ /ml. D-penicillamine is dissolved in 0.05 molar sodium acetate buffer, pH 5.6, containing 2% sodium chloride to give a concentration of 10 mg penicillamine/ml. The copper solution is added to the penicillamine solution in a ratio of 16 ml of copper solution to 50 ml of penicillamine solution. The ratio of penicillamine to copper in moles is 1.3. The solution immediately takes on a red-violet color indicating the formation of the complex. The solution is dried to yield a powder and formed into tablets each containing 10 mg of the combination.

Provenance & Evidence