反应详情

温度

95 °C

A solution of potassium hydroxide (88.4 g., 1.576 mole) in 10 liters of water is stirred and heated to 95° C.; then 1-propionyl-4-(2-phenoxyethyl)-semicarbazide (396.1 g., 1.576 mole) added and the mixture stirred at 95°-96° C. for a 40 min. period. Insolubles are collected and the filtrate stirred in an ice bath as 145 ml. (1.74 mole) of 37% hydrochloric acid is added. Stirring is continued with cooling to provide a white solid which is collected, rinsed with water and air dried to provide 233.5 g., (63.5% yield) of 5-ethyl-4-(2-phenoxyethyl)-2H-1,2,4-triazol-3(4H)-one, m.p. 136°-139° C.

1. customInsolubles are collected
2. stirringthe filtrate stirred in an ice bath as 145 ml
3. stirringStirring
4. temperaturewith cooling
5. customto provide a white solid which
6. customis collected
7. washrinsed with water and air
8. customdried
9. customto provide 233.5 g