Triethylamine → HCID 13369869, compound

HRID 1153982Notes

Reaction equation

HRID 1153982 reaction equation
Cl.[N:2]1([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH:14]=[CH:13]3)=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Cl:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](Cl)=[O:26].C(N(CC)CC)C>ClCCl>[Cl:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([N:5]1[CH2:6][CH2:7][N:2]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH:14]=[CH:13]3)=[O:9])[CH2:3][CH2:4]1)=[O:26]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 69252Benzoyl chloride, 3-chloro-HCID 13369865HCID 13369865, compound

Product 1

HCID 13369869HCID 13369869, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.0 Gram of 6-(1-piperazinylcarbonyl)carbostyril monohydrochloride, 0.72 g of m-chlorobenzoylchloride and 1.4 ml of triethylamine were suspended in 15 ml of dichloromethane and the suspension was stirred at a room temperature for 2 hours. Crystals formed in the reaction mixture were collected by filtration and recrystallized from dimethylformamide to obtain 1.07 g of 6-[4-(3-chlorobenzoyl)-1-piperazinylcarbonyl]-carbostyril. Colorless powdery crystals. Melting point: over 300° C.

Workup

  1. customCrystals formed in the reaction mixture
  2. filtrationwere collected by filtration
  3. customrecrystallized from dimethylformamide

Sources & evidence

ORD record
ord-c9091011872d47c8af589b2081d2c0b5
Source dataset
uspto-grants-1984_12
Patent number
US04487772

Reaction notes

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