反应详情

A solution of 16.9 g of tert.butyl 2-(2-ethoxycarbonylacetyl)hexahydropyridazine-3-carboxylate in 350ml of glacial acetic acid was heated at 100° C. for 1.5 hours. Evaporation gave an oil which was chromatographed on silica gel to yield 9.45 g (66%)of tert.butyl hexahydro-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in the form of a pale yellow solid having a melting point of 121°-122° C. (from chloroform/hexane).

1. customEvaporation
2. customgave an oil which
3. customwas chromatographed on silica gel