HCID 20435989, compound → HCID 20435943, compound

HRID 1154035Notes

Reaction equation

HRID 1154035 reaction equation
[CH3:1][C:2]1([CH2:17][CH2:18][O:19]C2CCCCO2)[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]>Cl.CO>[OH:19][CH2:18][CH2:17][C:2]1([CH3:1])[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]

Participants

4

Reactant 1

HCID 20435989HCID 20435989, compound

Product 1

HCID 20435943HCID 20435943, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of 3.52 g (0.01 mol) of methyl 2,3,5,8-tetrahydro-2-methyl-1,3-dioxo-2[2-(tetrahydro-2-pyranyloxy)ethyl]-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in 50 ml of 1M hydrochloric acid and 50 ml of methanol was stirred at room temperature for 1.5 hours. The solvent was removed by evaporation in vacuo. The solid residue was taken up in dichloromethane, dried over magnesium sulfate and evaporated to give 2.6 g (97%) of methyl 2,3,5,8-tetrahydro-2-(2-hydroxyethyl)-2-methyl-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate having a melting point of 97°-99° C. (from diethyl ether).

Workup

  1. customThe solvent was removed by evaporation in vacuo
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-4d5f6c5945fa446d9528c516b17a3c9e
Source dataset
uspto-grants-1984_12
Patent number
US04487929

Reaction notes

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