2-(2-acetylthioethyl)-2-ethyl-hexahydro-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylic acid → HCID 20435933, compound

HRID 1154041Notes

Reaction equation

HRID 1154041 reaction equation
C([S:4][CH2:5][CH2:6][C:7]1([CH2:21][CH3:22])[C:18](=[O:19])[N:10]2[CH2:11][CH2:12][CH2:13][CH:14]([C:15]([OH:17])=[O:16])[N:9]2[C:8]1=[O:20])(=O)C>Cl>[CH2:21]([C:7]1([CH2:6][CH2:5][SH:4])[C:18](=[O:19])[N:10]2[CH2:11][CH2:12][CH2:13][CH:14]([C:15]([OH:17])=[O:16])[N:9]2[C:8]1=[O:20])[CH3:22]

Participants

3

Reactant 1

HCID 204359422-(2-acetylthioethyl)-2-ethyl-hexahydro-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylic acid

Product 1

HCID 20435933HCID 20435933, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.33 g of 2-(2-acetylthioethyl)-2-ethyl-hexahydro-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylic acid was heated under reflux for 0.5 hour with 10 ml of 2M hydrochloric acid. After evaporation, the residue was dissolved in dichloromethane, the solution was dried over magnesium sulfate and then evaporated to give 0.27 g (94%) of 2-ethyl-hexahydro-2-(2-mercaptoethyl)-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylic acid in the form of a colorless foam.

Workup

  1. customAfter evaporation
  2. dissolutionthe residue was dissolved in dichloromethane
  3. dry with materialthe solution was dried over magnesium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-87915600f8d8437ead3198a2c3386902
Source dataset
uspto-grants-1984_12
Patent number
US04487929

Reaction notes

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