Hydrochloric Acid → HCID 20436001, compound

HRID 1154042Notes

Reaction equation

HRID 1154042 reaction equation
C([S:4][CH2:5][CH2:6][C:7]1([CH3:22])[C:19](=[O:20])[N:10]2[CH2:11][CH:12]=[CH:13][CH:14]([C:15]([O:17]C)=[O:16])[N:9]2[C:8]1=[O:21])(=O)C.Cl>>[SH:4][CH2:5][CH2:6][C:7]1([CH3:22])[C:19](=[O:20])[N:10]2[CH2:11][CH:12]=[CH:13][CH:14]([C:15]([OH:17])=[O:16])[N:9]2[C:8]1=[O:21]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20435958HCID 20435958, compound

Product 1

HCID 20436001HCID 20436001, compoundYield 38.4%

Procedure

1.1 g of methyl 2-(2-acetylthioethyl)-2,3,5,8-tetrahydro-2-methyl-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate (diastereomer A) were heated under reflux for 3 hours with 25 ml of 2 M hydrochloric acid. After evaporation, the residue was taken up in dichloromethane, the solution was dried over magnesium sulfate and then evaporated. There was obtained 0.35 g (38%) of 2,3,5,8-tetrahydro-2-(2-mercaptoethyl)-2-methyl-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylic acid (diastereomer A) in the form of a white solid having a melting point of 113°-114° C. (from diethyl ether/petroleum ether).

Workup

  1. customAfter evaporation
  2. dry with materialthe solution was dried over magnesium sulfate
  3. customevaporated

Sources & evidence

ORD record
ord-9650124b700747f28cb2082295556d35
Source dataset
uspto-grants-1984_12
Patent number
US04487929

Reaction notes

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