Sodium Iodide → HCID 86738973, compound

HRID 1154055Notes

Reaction equation

HRID 1154055 reaction equation
CS(O[CH2:6][CH2:7][C:8]1([CH3:25])[CH2:23][N:11]2[CH2:12][CH2:13][CH2:14][CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]2[C:9]1=[O:24])(=O)=O.[I-].[Na+].[C:28]([O-:31])(=[S:30])[CH3:29].[K+]>CC(C)=O>[C:28]([S:30][CH2:6][CH2:7][C:8]1([CH3:25])[CH2:23][N:11]2[CH2:12][CH2:13][CH2:14][CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:17])[N:10]2[C:9]1=[O:24])(=[O:31])[CH3:29]

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 23670855Potassium ethanethioateHCID 86738974HCID 86738974, compound

Product 1

HCID 86738973HCID 86738973, compoundYield 59.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 0.77 g tert.butyl hexahydro-2(2-methanesulfonyloxyethyl)-2-methyl-3-oxo-1H-pyrazolo[1,2-a]-pyridazine-5-carboxylate (diastereomer A) in 20 ml of acetone was treated with 0.3 g of sodium iodide and 0.23 g of potassium thioacetate. The mixture was then stirred at room temperature for 24 hours and subsequently evaporated. After chromatography of the residue on silica gel, there was obtained 0.43 g (59%) of tert.butyl hexahydro-2-(2-acetylthioethyl)-2-methyl-3-oxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate (diastereomer A) in the form of an oil.

Workup

  1. customsubsequently evaporated

Sources & evidence

ORD record
ord-ab0e269de45f4f42b9f170f5e01a9223
Source dataset
uspto-grants-1984_12
Patent number
US04487929

Reaction notes

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