HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → Z-Tyr(But)-Phe-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | O-(1,1-Dimethylethyl)-N-((phenylmethoxy)carbonyl)-L-tyrosine | HCID 978520 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Tyr(But)-Phe-OMe | HCID 13178789 | — |
Reaction Steps
13 ml of N-ethylmorpholine and 22 g of DCC are added at 0° C. to a solution of 40.7 g (0.1 mmole) of Z-Tyr(But)-OH, 21.6 g of H-Phe-OMe hydrochloride and 13.5 g (0.1 mmole) of HOBt in 200 ml of dimethylformamide. The mixture is worked up as in the case of Example 1 a. The residue is triturated with petroleum ether and suction-drained. Yield 50.3 g (94%), melting point 103°-104° C., [α]D24 =-12.3° (c=1, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04487764 |
| Source dataset | uspto-grants-1984_12 |
| ORD ID | ord-562cb76d7f5240d1945f86ee86848e4f |
| Source note | uspto-grants-1984_12 |