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HRID1154153

反应详情

EQUATION

反应方程式

HRID 1154153 的结构方程式

REACTANTS

反应物

5
结构：CCN1CCOCC1
HCID7525

N-Ethylmorpholine

C6H13NO

结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：COC(=O)[C@@H](N)Cc1ccccc1.Cl
HCID75736

Methyl L-phenylalaninate hydrochloride (1:1)

C10H14ClNO2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)(C)Oc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)O)cc1
HCID978520

Z-TYR(TBU)-OH

C21H25NO5

PRODUCTS

生成物

1
结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCc1ccccc1
HCID13178789

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

13 ml of N-ethylmorpholine and 22 g of DCC are added at 0° C. to a solution of 40.7 g (0.1 mmole) of Z-Tyr(But)-OH, 21.6 g of H-Phe-OMe hydrochloride and 13.5 g (0.1 mmole) of HOBt in 200 ml of dimethylformamide. The mixture is worked up as in the case of Example 1 a. The residue is triturated with petroleum ether and suction-drained. Yield 50.3 g (94%), melting point 103°-104° C., [α]D24 =-12.3° (c=1, methanol).

WORKUP

后处理

  1. customThe residue is triturated with petroleum ether
  2. customYield 50.3 g (94%), melting point 103°-104° C., [α]D24 =-12.3° (c=1, methanol)