反应详情

To a solution of benzhydryl 7-(5-benzhydryloxycarbonyl-5-ethoxycarbonylaminopentanamido)-3-hydroxymethyl-3-cephem-4-carboxylate (18 g) in ethylene chloride (180 ml) were added phosphorus pentachloride (4.82 g) and pyridine (1.83 g) at -30° to -35° C. After stirring for 30 minutes, to the solution was added water (180 ml), and the organic layer was separated and washed with an aqueous sodium chloride. The solution was evaporated, and the residue was dissolved in N,N-dimethylformamide (39 ml). To the solution was added triphenylphosphine (6.66 g) and sodium iodide (3.81 g) at ambient temperature. After stirring for an hour, the mixture was added to diisopropyl alcohol (1000 ml) at 0°-5° and allowed to stand for an hour. The precipitates were collected by filtration, washed with diisopropyl alcohol, and then dissolved in ethylene chloride (160 ml). To the solution were added water (35.3 ml) and 36% aqueous formaldehyde, and the mixture was stirred at ambient temperature for 70 minutes while maintaining the pH value at 9.0 with 40 % aqueous potassium carbonate. The organic layer was separated, washed with an aqueous sodium chloride and dried over magnesium sulfate. The solution was evaporated, and the residue was dissolved in acetone (30 ml). To diisopropyl ether (300 ml) was added the acetone solution. The precipitates were collected by filtration and washed with diisopropyl ether to afford benzhydryl 7-(5-benzhydryloxycarbonyl-5-ethoxycarbonylaminopentanamido)-3-vinyl-3-cephem-4-carboxylate (9.82 g).

1. customthe organic layer was separated
2. washwashed with an aqueous sodium chloride
3. customThe solution was evaporated
4. dissolutionthe residue was dissolved in N,N-dimethylformamide (39 ml)
5. additionTo the solution was added triphenylphosphine (6.66 g) and sodium iodide (3.81 g) at ambient temperature
6. stirringAfter stirring for an hour
7. additionthe mixture was added to diisopropyl alcohol (1000 ml) at 0°-5°
8. waitto stand for an hour
9. filtrationThe precipitates were collected by filtration
10. washwashed with diisopropyl alcohol
11. dissolutiondissolved in ethylene chloride (160 ml)
12. additionTo the solution were added water (35.3 ml) and 36% aqueous formaldehyde
13. stirringthe mixture was stirred at ambient temperature for 70 minutes
14. temperaturewhile maintaining the pH value at 9.0 with 40 % aqueous potassium carbonate
15. customThe organic layer was separated
16. washwashed with an aqueous sodium chloride
17. dry with materialdried over magnesium sulfate
18. customThe solution was evaporated
19. dissolutionthe residue was dissolved in acetone (30 ml)
20. additionTo diisopropyl ether (300 ml) was added the acetone solution
21. filtrationThe precipitates were collected by filtration
22. washwashed with diisopropyl ether