Water → N-(((2,6-Dichlorophenyl)amino)thioxomethyl)benzamide

HRID 1154289노트

반응식

HRID 1154289 반응식
[S-:1][C:2]#[N:3].[NH4+].[C:5](Cl)(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl:14][C:15]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:16]=1[NH2:17].O>CC(C)=O>[Cl:14][C:15]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:16]=1[NH:17][C:2]([NH:3][C:5](=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[S:1]

참가 물질

6

반응물 4

HCID 962WaterHCID 7412Benzoyl chlorideHCID 118462,6-DichloroanilineHCID 15666Ammonium thiocyanate

생성물 1

HCID 702451N-(((2,6-Dichlorophenyl)amino)thioxomethyl)benzamide

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

To 51.8 g. (0.68 mole) of ammonium thiocyanate in 300 ml acetone is added 86.8 g (0.62 mole) of benzoyl chloride. The reaction mixture is refluxed for about 5 min. and then 100 g (0.62 mole) of 2,6-dichloroaniline in 200 ml acetone is added at a rate to maintain reflux. The mixture is refluxed for 11/2 hours, cooled, poured into 11/2 liters of ice and water, filtered to obtain 1-(2,6-dichlorophenyl)-3-benzoylthiourea.

후처리

  1. temperatureThe reaction mixture is refluxed for about 5 min.
  2. temperatureto maintain
  3. temperaturereflux
  4. temperatureThe mixture is refluxed for 11/2 hours
  5. temperaturecooled
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-77ce7a4999884cdf83ce9636c546dfa0
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04488993

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