HCID 140327414, compound → [N-(2,6-dichlorophenyl)-N-methylcarbamimidoyl]urea

HRID 1154292Notes

Reaction equation

HRID 1154292 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]([CH3:20])[C:10]([NH:12][C:13]([NH:15]C(C)(C)C)=[O:14])=[NH:11]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]([CH3:20])[C:10]([NH:12][C:13]([NH2:15])=[O:14])=[NH:11]

Participants

3

Reactant 1

HCID 140327414HCID 140327414, compound

Product 1

HCID 140327406[N-(2,6-dichlorophenyl)-N-methylcarbamimidoyl]urea

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture os 33.7 g (0.106 mole) of 1-(2,6-dichlorophenyl-N-methylamidino)-3-(t-butyl)urea and 200 ml of conc. hydrochloric acid is refluxed for 1/2 hour. The reaction mixture is cooled, filtered and washed with 10 ml of 1:1 HCl/H2O and dried. The product is then recrystallized from ethanol-ether to obtain 1-(2,6-dichlorophenyl-N-methylamidino)urea.

Workup

  1. temperatureThe reaction mixture is cooled
  2. filtrationfiltered
  3. washwashed with 10 ml of 1:1 HCl/H2O
  4. customdried
  5. customThe product is then recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-1db37dd09c3f4bbd8a7917343833c41b
Source dataset
uspto-grants-1984_12
Patent number
US04488993

Reaction notes

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