1-(2,6-Dichlorophenyl)3-(t-butylcarbamyl)thiourea → 1-(2,6-Dichlorophenyl)-3-carbamylthiourea

HRID 1154294Notes

Reaction equation

HRID 1154294 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:19])[NH:14]C(C)(C)C)=[S:11]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:19])[NH2:14])=[S:11]

Participants

3

Reactant 1

HCID 204346311-(2,6-Dichlorophenyl)3-(t-butylcarbamyl)thiourea

Product 1

HCID 204344241-(2,6-Dichlorophenyl)-3-carbamylthiourea

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 32 g (0.1 mole) of 1-(2,6-dichlorophenyl)-3-(t-butylcarbamyl)thiourea and 200 ml of conc. hydrochloric acid is refluxed for 1/2 hour. The reaction mixture is cooled, filtered and washed with 10 ml of 1:1 HCl/H2O and dried. The product is then recrystallized from ethanol-ether to obtain 1-(2,6-dichlorophenyl)-3-carbamylthiourea.

Workup

  1. temperatureis refluxed for 1/2 hour
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. washwashed with 10 ml of 1:1 HCl/H2O
  5. customdried
  6. customThe product is then recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-dab20c9387d340cda0ec8a4bcbed35b3
Source dataset
uspto-grants-1984_12
Patent number
US04488993

Reaction notes

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