Isopropylamine → HCID 86739791, compound

HRID 1154299Notes

Reaction equation

HRID 1154299 reaction equation
[C:1]([NH:5][C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:21])[C:14]([CH3:20])([CH3:19])[CH2:15][C:16]([OH:18])=[O:17])[CH:9]=[CH:10][CH:11]=1)(=[O:4])[CH2:2][CH3:3].C(N)(C)C>O1CCCC1>[CH:6]([NH2:5])([CH3:7])[CH3:11].[C:1]([NH:5][C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:21])[C:14]([CH3:20])([CH3:19])[CH2:15][C:16]([OH:18])=[O:17])[CH:9]=[CH:10][CH:11]=1)(=[O:4])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 20434845HCID 20434845, compound

Product 1

HCID 86739791HCID 86739791, compoundYield 183%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Two grams N-[3-propionamido(phenyl)]-3,3-dimethyl succinamic acid prepared by the general method above was dissolved in 25 ml tetrahydrofuran. The solution was stirred at room temperature and 0.45 g of isopropylamine dissolved in tetrahydrofuran was added dropwise. The reaction mixture was stirred for about 2.5 hours. Rotary evaporation yielded 2.2 g of the title product. This compound will be referred to as Compound No. 7.

Workup

  1. additionwas added dropwise
  2. stirringThe reaction mixture was stirred for about 2.5 hours
  3. customRotary evaporation

Sources & evidence

ORD record
ord-ada287397b784ab1a13898b867532688
Source dataset
uspto-grants-1984_12
Patent number
US04489010

Reaction notes

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