3-Chlorobenzo(b)thiophene-2-carbonyl chloride → 3-Chloro-N-[2-(1H-imidazol-1-yl)ethyl]benzo[b]thiophene-2-carboxamide

HRID 1154330Notes

Reaction equation

HRID 1154330 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][NH2:10])[CH:7]=[CH:6][N:5]=[CH:4]1.[Cl:11][C:12]1[C:13]2[CH:23]=[CH:22][CH:21]=[CH:20][C:14]=2[S:15][C:16]=1[C:17](Cl)=[O:18]>>[Cl:11][C:12]1[C:13]2[CH:23]=[CH:22][CH:21]=[CH:20][C:14]=2[S:15][C:16]=1[C:17]([NH:10][CH2:9][CH2:8][N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[O:18]

Participants

3

Reactant 2

HCID 5198983-Chlorobenzo(b)thiophene-2-carbonyl chlorideHCID 123779132-(Imidazol-1-yl)-ethylamine dihydrochloride

Product 1

HCID 133710833-Chloro-N-[2-(1H-imidazol-1-yl)ethyl]benzo[b]thiophene-2-carboxamide

Procedure

A 1.47 g. portion of 1H-imidazole-1-ethanamine dihydrochloride was reacted with 3-chloro-benzo[b]thiophene-2-carbonyl chloride as described in Example 1, giving 0.75 g. of the desired product, m.p. 132°-134° C.

Workup

  1. customgiving 0.75 g

Sources & evidence

ORD record
ord-ef45f4628b9a4d17af341ec4b9d2a7f7
Source dataset
uspto-grants-1984_12
Patent number
US04489089

Reaction notes

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