反应详情

A mixture of 23.5 g. of N-(4-chloro-2-butenyl)-isoindole-1,3(2H)-dione, 11.0 g. of sodium imidazole and 200 ml. of dimethyl formamide was heated on the steam bath for 18 hours and concentrated to remove the solvent; the residue was taken up in methylene chloride, washed with water, dried with magnesium sulfate and again concentrated. The residue was dissolved in hot ethylacetate and allowed to cool and N-[4-(1H-imidazol-1-yl)-2-butenyl]isoindole-1,3-(2H)-dione, m.p. 106°-108° C., was obtained.

1. additionA mixture of 23.5 g
2. concentrationconcentrated
3. customto remove the solvent
4. washwashed with water
5. dry with materialdried with magnesium sulfate
6. concentrationagain concentrated
7. dissolutionThe residue was dissolved in hot ethylacetate
8. temperatureto cool