反应详情

A 1.80 g. portion of 4-[[3-(p-chlorophenyl)propyl]methylamino]benzoic acid, ethyl ester is dissolved in 15 ml. of 95% ethanol. A 1 g. portion of potassium hydroxide is added, and the mixture is refluxed overnight. The solution is poured into 30 ml. of water, the pH is adjusted to 6 using 37% hydrochloric acid, and the solid is collected and dried. This solid is dissolved in benzene, filtered, and evaporated, giving 750 mg. of the desired product.

1. temperaturethe mixture is refluxed overnight
2. additionThe solution is poured into 30 ml
3. customthe solid is collected
4. customdried
5. dissolutionThis solid is dissolved in benzene
6. filtrationfiltered
7. customevaporated
8. customgiving 750 mg