Methyl iodide → HCID 178503360, compound

HRID 1154385Notes

Reaction equation

HRID 1154385 reaction equation
O.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[C:18]3[NH:17][C:16](=[S:19])[NH:15][C:14]=3[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][N:23]=[C:11]23)=[CH:5][CH:4]=1.I[CH3:25]>[OH-].[Na+]>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[C:18]3[NH:17][C:16]([S:19][CH3:25])=[N:15][C:14]=3[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][NH:23][CH:11]23)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 202177034-[(4-CHLOROPHENYL)METHYL]-2,3,6,7-TETRAHYDRO-2-THIOXO-1H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE MONOHYDRATE

Product 1

HCID 178503360HCID 178503360, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a solution of the product of Procedure 97 (2.4 g., 0.0068 mole) in 0.1N NaOH (85 ml.), iodomethane (1.94 g., 0.0136 mole) was added and the mixture stirred at room temperature for 16 hrs. The insolubles were collected and recrystallized from methoxyethanol to give 1.3 g. of product, m.p. 296°-297°.

Workup

  1. customThe insolubles were collected
  2. customrecrystallized from methoxyethanol
  3. customto give 1.3 g

Sources & evidence

ORD record
ord-05fe63d77b1c4a979b0aafcc13034709
Source dataset
uspto-grants-1984_12
Patent number
US04489078

Reaction notes

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