Hydrochloric Acid → HCID 13365016, compound

HRID 1154564Notes

Reaction equation

HRID 1154564 reaction equation
C1O[CH:4]([C:5]2[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:6]=2[NH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[O:3]C1.Cl>CC(C)=O>[C:16]([NH:15][C:6]1[CH:7]=[CH:8][C:9]([O:13][CH3:14])=[C:10]([O:11][CH3:12])[C:5]=1[CH:4]=[O:3])([O:18][CH2:19][CH3:20])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13365015HCID 13365015, compound

Product 1

HCID 13365016HCID 13365016, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(N-Carbethoxyamino)-5,6-dimethoxybenzaldehyde-ethyleneketal (5.0 g, 16.8 mM) is dissolved in acetone (36 ml) and aqueous HCl (3 ml of 1N solution). The mixture is stirred at room temperature for 4 hours. The solvent is removed in vacuo to give a yellow solid (3.9 g). Recrystallization from n-hexane gives the pure product as a yellow solid; yield 3.6 g (84.7%); m.p. 86°-88° C.

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-b82b0943c8f040069002d19cc8d00dff
Source dataset
uspto-grants-1984_12
Patent number
US04490374

Reaction notes

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