Acetic Acid → HCID 53756085, compound

HRID 1154574Notes

Reaction equation

HRID 1154574 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].C(Cl)(=O)C.CS(O[C:14]1[CH:19]=[CH:18][C:17]([CH:20]=[CH:21][C:22](=[NH:24])[NH2:23])=[CH:16][CH:15]=1)(=O)=O>C(OCC)C>[C:1]([O:4][C:14]1[CH:19]=[CH:18][C:17]([CH:20]=[CH:21][C:22](=[NH:23])[NH2:24])=[CH:16][CH:15]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6367Acetyl chlorideHCID 54417104HCID 54417104, compound

Product 1

HCID 53756085HCID 53756085, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of 8 ml of glacial acetic acid and 8 ml of acetyl chloride, was added 2.0 g of 4-(β-amidinoethenyl)phenol methanesulfonate. The mixture was heated with stirring under reflux for one hour. After cooling, the reaction mixture was mixed with ethyl ether to precipitate a white solid substance which was recrystallized from ethanol to yield 1.8 g of colorless needle crystals of 4-(β-amidinoethenyl)phenyl acetate methanesulfonate.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for one hour
  3. temperatureAfter cooling
  4. customto precipitate a white solid substance which
  5. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-8991c4e67d3941429f08c9bd5816ad87
Source dataset
uspto-grants-1984_12
Patent number
US04490388

Reaction notes

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