(+-)-3,4-Dimethoxyamphetamine → alpha-(alpha-Methyl-3,4-dimethoxyphenethylimino)-2-benzyloxyacetophenone

HRID 1154603Notes

Reaction equation

HRID 1154603 reaction equation
[OH2:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([CH:18]=O)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:20][CH:21]([NH2:33])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1>CS(C)=O>[CH3:20][CH:21]([N:33]=[C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[C:15]([C:14]1[CH:13]=[CH:12][CH:11]=[CH:16][CH:18]=1)=[O:1])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1

Participants

4

Reactant 2

HCID 8423(+-)-3,4-DimethoxyamphetamineHCID 204340852-Benzyloxyphenylglyoxal hydrate

Product 1

HCID 20434087alpha-(alpha-Methyl-3,4-dimethoxyphenethylimino)-2-benzyloxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

2.3 g of 2-benzyloxyphenylglyoxal hydrate (crude oil) are dissolved in 6 ml of dimethylsulfoxide, and 2 g of α-methyl-3,4-dimethoxyphenethylamine are added thereto. The mixture is stirred at room temperature for 30 minutes, whereby a solution of α-(α-methyl-3,4-dimethoxyphenethylimino)-2-benzyloxyacetophenone in dimethylsulfoxide is obtained.

Sources & evidence

ORD record
ord-2cff76dbea424330b3a1a01aaa108953
Source dataset
uspto-grants-1984_12
Patent number
US04490392

Reaction notes

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