3,4-Methylenedioxyamphetamine → alpha-(alpha-Methyl-3,4-methylenedioxyphenethylimino)-2-benzyloxyacetophenone

HRID 1154625Notes

Reaction equation

HRID 1154625 reaction equation
[OH2:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([CH:18]=O)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:20][CH:21]([NH2:32])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1>CS(C)=O>[CH3:20][CH:21]([N:32]=[C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[C:15]([C:14]1[CH:13]=[CH:12][CH:11]=[CH:16][CH:18]=1)=[O:1])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1

Participants

4

Reactant 2

HCID 16143,4-MethylenedioxyamphetamineHCID 204340852-Benzyloxyphenylglyoxal hydrate

Product 1

HCID 86739856alpha-(alpha-Methyl-3,4-methylenedioxyphenethylimino)-2-benzyloxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

5.2 g of 2-benzyloxyphenylglyoxal hydrate (crude oil) are dissolved in 15 ml of dimethylsulfoxide, and 3.54 g of α-methyl-3,4-methylenedioxyphenethylamine are added thereto. The mixture is treated in the same manner as described in Example 1-(2), whereby a solution of α-(α-methyl-3,4-methylenedioxyphenethylimino)-2-benzyloxyacetophenone in dimethylsulfoxide is obtained.

Workup

  1. additionThe mixture is treated in the same manner

Sources & evidence

ORD record
ord-fb41cacd0f614cb9b380a237e683548b
Source dataset
uspto-grants-1984_12
Patent number
US04490392

Reaction notes

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