Acetic Acid → 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

Participants

Reaction Steps

A solution of 600.6 gm of N-(2,2-dimethoxyethyl)-3,4-dimethoxyphenyl-acetamide in 3 liters of concentrated hydrochloric acid was mixed with 3 liters of glacial acetic acid. After standing for 17 hours at room temperature, the mixture was poured over ice. The crystals precipitated thereby were suction-filtered off, washed with water until neutral and dried.

Provenance & Evidence