Acetic Acid → 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

HRID 1154631Notes

Reaction equation

HRID 1154631 reaction equation
CO[CH:3](OC)[CH2:4][NH:5][C:6](=[O:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1.C(O)(=O)C>Cl>[CH3:15][O:14][C:11]1[C:10]([O:16][CH3:17])=[CH:9][C:8]2[CH2:7][C:6](=[O:18])[NH:5][CH:4]=[CH:3][C:13]=2[CH:12]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 13092500n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide

Product 1

HCID 14823731,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 600.6 gm of N-(2,2-dimethoxyethyl)-3,4-dimethoxyphenyl-acetamide in 3 liters of concentrated hydrochloric acid was mixed with 3 liters of glacial acetic acid. After standing for 17 hours at room temperature, the mixture was poured over ice. The crystals precipitated thereby were suction-filtered off, washed with water until neutral and dried.

Workup

  1. additionthe mixture was poured over ice
  2. customThe crystals precipitated
  3. filtrationthereby were suction-filtered off
  4. washwashed with water until neutral and
  5. customdried

Sources & evidence

ORD record
ord-212f45098a2742bdad1ce58ccf09e0d9
Source dataset
uspto-grants-1984_12
Patent number
US04490369

Reaction notes

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