Nitric Acid → 8-Methoxy-7-nitro-1,3,4,5-tetrahydro-benzo[d]azepin-2-one
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][NH:10][C:9](=[O:13])[CH2:8][C:7]=2[CH:14]=1.[N+:15]([O-])([OH:17])=[O:16].C(=O)([O-])[O-].[K+].[K+]>>[N+:15]([C:4]1[C:3]([O:2][CH3:1])=[CH:14][C:7]2[CH2:8][C:9](=[O:13])[NH:10][CH2:11][CH2:12][C:6]=2[CH:5]=1)([O-:17])=[O:16]Participants
4
Procedure
765 mg (4 mmol) of 8-methoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one were added to a mixture of 15 ml of concentrated nitric acid and 1.5 ml of fuming nitric acid at a temperature between 3° and 5° C., while stirring. After stirring at this temperature for 30 minutes more, the mixture was poured into ice water, and the aqueous mixture was neutralized with potassium carbonate. The precipitate formed thereby was suction-filtered off, washed with water and dried. The yellow crystals were purified by chromatography on silica gel, using ethyl acetate as the eluant, to separate the corresponding 9-nitro- and 7,9-dinitro-isomers.
Workup
- stirringAfter stirring at this temperature for 30 minutes more
- customThe precipitate formed
- filtrationthereby was suction-filtered off
- washwashed with water
- customdried
- customThe yellow crystals were purified by chromatography on silica gel
- customto separate the corresponding 9-nitro- and 7,9-dinitro-isomers
Sources & evidence
- ORD record
- ord-3cbe21cf6c524f648c503074273fe8fe
- Source dataset
- uspto-grants-1984_12
- Patent number
- US04490369
Reaction notes
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