反应详情

To a stirred and cooled (ice-bath) mixture of 5 parts of N,N'-methanetetraylbis[cyclohexanamine], 25.2 parts of carbon disulfide and 40 parts of pyridine are added 6 parts of 4-[4-(4-methoxyphenyl)-1-piperazinyl]benzenamine and the whole is stirred first for 1 hour in an ice-bath and further for 2 hours at room temperature. 35 Parts of 2,2'-oxybispropane are added and the whole is stirred for 30 minutes. The precipitated product is filtered off and crystallized from 4-methyl-2-pentanone. The product is filtered off again and recrystallized from 1,4-dioxane, yielding 2.45 parts of 1-(4-isothiocyanatophenyl)-4-(4-methoxyphenyl)piperazine; mp. 180.6° C.

1. temperaturecooled
2. stirringthe whole is stirred first for 1 hour in an ice-bath and further for 2 hours at room temperature
3. stirringthe whole is stirred for 30 minutes
4. filtrationThe precipitated product is filtered off
5. customcrystallized from 4-methyl-2-pentanone
6. filtrationThe product is filtered off again
7. customrecrystallized from 1,4-dioxane