反应详情

A mixture of 12.5 parts of N,N-bis(2-chloroethyl)-4-methoxybenzenamine, 8 parts of 4-(1H-pyrazol-1-yl)benzenamine, 2 parts of potassium iodide, 80 parts of 2-propanone and 100 parts of water is stirred and refluxed for 24 hours. The reaction mixture is cooled. The precipitated product is filtered off (the filtrate is set aside), washed with water and with 2-propanone, yielding a first crude fraction of 6 parts. The filtrate (see above) is neutralized with a sodium hydrogen carbonate solution and extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is triturated in 2-propanol. The product is filtered off and washed with methanol, yielding a second crude fraction of 2 parts. The combined crude crops (resp. 6 and 2 parts) are crystallized from 1-butanol, yielding 7.1 parts of 1-(4-methoxyphenyl)-4-[4-(1H-pyrazol-1-yl)phenyl]piperazine; mp. 207.7° C.

1. temperaturerefluxed for 24 hours
2. temperatureThe reaction mixture is cooled
3. filtrationThe precipitated product is filtered off (the filtrate
4. washwashed with water and with 2-propanone
5. customyielding a first crude fraction of 6 parts
6. extractionextracted with trichloromethane
7. customThe extract is dried
8. filtrationfiltered
9. customevaporated
10. customThe residue is triturated in 2-propanol
11. filtrationThe product is filtered off
12. washwashed with methanol
13. customyielding a second crude fraction of 2 parts
14. customare crystallized from 1-butanol