4-Bromophenacyl bromide → HCID 12953425, compound

HRID 1154892Notes

Reaction equation

HRID 1154892 reaction equation
[CH:1]1[C:6]([C:7]([CH2:9]Br)=O)=[CH:5][CH:4]=[C:3]([Br:11])[CH:2]=1.[CH2:12]([O:14][C:15](=[O:20])[CH2:16][C:17](=[S:19])[NH2:18])[CH3:13]>C(O)C>[CH2:12]([O:14][C:15](=[O:20])[CH2:16][C:17]1[S:19][CH:9]=[C:7]([C:6]2[CH:5]=[CH:4][C:3]([Br:11])=[CH:2][CH:1]=2)[N:18]=1)[CH3:13]

Participants

4

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 2771567ethyl 3-amino-3-thioxopropanoate

Product 1

HCID 12953425HCID 12953425, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of p-α-dibromoacetophenone (13.9 g, 0.05 mole) and 2-thiocarbamoylacetic acid ethyl ester in ethanol (65 ml) was heated under reflux for 21/2 hours. On cooling, there was obtained the title compound (12.2 g) mp 189°-191° C. (dec). An analytical sample recrystallization from ethanol had mp 191°-193° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 21/2 hours
  3. temperatureOn cooling

Sources & evidence

ORD record
ord-ffb5179111564060a8983e65a3d403c9
Source dataset
uspto-grants-1981_11
Patent number
US04298743

Reaction notes

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