4-Toluenesulfonyl chloride → HCID 20504739, compound

HRID 1154896Notes

Reaction equation

HRID 1154896 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([NH2:17])=O)[N:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].C1(C)C=CC(S(Cl)(=O)=O)=CC=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]#[N:17])[N:13]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 12953411HCID 12953411, compound

Product 1

HCID 20504739HCID 20504739, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To 2-[2-(3,4-dichlorophenyl)thiazol-4-yl]-acetamide (2.87 g., 0.01 mole) in pyridine (30 ml.) is added gradually p-toluenesulfonyl chloride (1.91 g., 0.01 mole). After stirring for one hour, the mixture is poured into excess ice-water to give the title compound.

Sources & evidence

ORD record
ord-cc3549e921864982919a71cba0fdc6a4
Source dataset
uspto-grants-1981_11
Patent number
US04298743

Reaction notes

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