Methyl chloroformate → HCID 20551614, compound

HRID 1154902Notes

Reaction equation

HRID 1154902 reaction equation
[CH3:1][C:2]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:8]([CH3:14])[NH:7][N:6]=1.[C:20](Cl)(=[O:23])[O:21][CH3:22]>C(N(CC)CC)C>[CH3:22][O:21][C:20]([N:7]1[C:8]([CH3:14])=[C:9]([C:10]([O:12][CH3:13])=[O:11])[C:5]([O:4][C:3]2[CH:15]=[CH:16][CH:17]=[C:18]([CH3:19])[C:2]=2[CH3:1])=[N:6]1)=[O:23]

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 178498938HCID 178498938, compound

Product 1

HCID 20551614HCID 20551614, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of 5.6 g of triethylamine, 13 g of 3-(2',3'-dimethylphenoxy)-5-methyl-4-methoxycarbonyl pyrazole and 100 ml of tetahydrofuran is prepared, and, while stirring and cooling, 4.9 g of methyl chlorocarbonate is dripped in. After stirring for 16 hours, the precipitated hydrochloride is filtered off. The filtrate is concentrated and the residue is recrystallized from ethyl acetate. Melting point: 115° C.

Workup

  1. customis prepared
  2. temperaturecooling
  3. stirringAfter stirring for 16 hours
  4. filtrationthe precipitated hydrochloride is filtered off
  5. concentrationThe filtrate is concentrated
  6. customthe residue is recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-faea038f8a59484c84cb25a339d43d17
Source dataset
uspto-grants-1981_11
Patent number
US04298749

Reaction notes

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