Hydrochloric Acid → 1-Bromo-2-ethoxyhexane

Temperature

20 °C

To a stirred solution of 1.68 moles of n-butylmagnesium bromide, as a 1.7M solution in ether, is added dropwise a solution of 300 g. of 1,2-dibromo-2-ethoxyethane in 750 ml. of ether during a period of 2 hours at -15° C. The resulting mixture is stirred for one hour while warming to 20° C., then cooled to 0° C., and treated while stirring with 500 ml. of water, followed by 100 ml. of 4N hydrochloric acid. The organic layer is washed with brine, dried over magnesium sulfate and concentrated. The residue is distilled to provide a colorless liquid, b.p. 83°-84° C., 18 mm.

1. temperaturecooled to 0° C.
2. additiontreated
3. stirringwhile stirring with 500 ml
4. washThe organic layer is washed with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated
7. distillationThe residue is distilled
8. customto provide a colorless liquid, b.p. 83°-84° C., 18 mm

ORD record

ord-12d01f6955ff4ff587bb803cbded4b63

Source dataset

uspto-grants-1981_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04298754