Triethylamine → HCID 178418780, compound

HRID 11550Notes

Reaction equation

HRID 11550 reaction equation
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][CH2:6][CH:5]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH2:4]1.[F:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[C:22]2=[CH:29]O.CCN(CC)CC>>[F:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[C:22]2=[CH:29][NH:17][C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][N:3]([CH3:2])[CH2:4]2)=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 699769594-(1-Methylpiperidin-3-ylmethoxy)-phenylamine hydrochlorideHCID 178418836HCID 178418836, compound

Product 1

HCID 178418780HCID 178418780, compoundYield 77.2%

Procedure

In a manner similar to that described in Example 231, 4-(1-methyl-piperidin-3-ylmethoxy)-phenylamine hydrochloride (688 mg, 1.2 equiv.) and 5-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (400 mg, 2.23 mmol, 1 equiv.) with the addition of anhydrous Et3N (2.25 equiv.) are reacted to give the named compound as a yellow solid (657 mg, 77%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-2f938834d6b24fafa5b503cac5b7493d
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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